Search results for "Binucleated cells"

showing 3 items of 3 documents

Binucleate cells in the Ehrlich ascites tumor. Autoradiographic labeling

1989

Abstract An autoradiographic study was performed on binucleate and mitotic cells in the Ehrlich ascites tumor (EAT) untreated and after treatment with 5-fluorouracil (FU). The number of binucleate cells was greater in the treated tumor than in the controls. It was also observed that the number of labeled mitoses was greater in the Fu-treated tumor. Autoradiographic labeling showed that the cells that proved to be binucleate had previously passed through S-phase; thus, these cells belonged to the proliferative compartment.

Cell NucleusPathologymedicine.medical_specialtyBinucleated cellsMice Inbred StrainsCell BiologyGeneral MedicineCompartment (chemistry)BiologyTritiumEhrlich ascitesMiceBiochemistryMitotic IndexmedicineAnimalsAutoradiographyFemaleFluorouracilCarcinoma Ehrlich TumorMitosisAfter treatmentThymidineBiology of the Cell
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Possible relationship between micronucleated and binucleated cells induced by cisplatin in cultured CHO cells

1993

Abstract Chinese hamster ovary (CHO) cells were treated with a single dose (10 μg/ml) of cis-diammino-dichloroplatinum (II) (cisplatin) for 1 h and the effect of the drug on the kinetics of proliferation of the cultures was studied. It was found that the drug produces a delay in the proliferation rates of the treated cultures. The induction of micronuclei and binucleated cells (BC) at different times after treatment have also been studied, and the ability of these cells to undergo DNA synthesis (measured as the ability to incorporate [3H]thymidine) is shown. It was found that cisplatin induced a particular type of BC that contains one or more micronuclei rather than a pure population of BC.…

Cisplatineducation.field_of_studyDNA synthesisChinese hamster ovary cellBinucleated cellsPopulationHamsterCHO CellsBiologyToxicologycomplex mixturesMolecular biologychemistry.chemical_compoundchemistryCricetinaeMicronucleus testGeneticsmedicineAnimalsCisplatineducationThymidineCell DivisionMicronuclei Chromosome-Defectivemedicine.drugMutation Research/Environmental Mutagenesis and Related Subjects
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Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.

2012

Abstract Mangiferin is a glucosylxantone isolated from Mangifera indica L. stem bark. Several studies have shown its pharmacological properties which make it a promising candidate for putative therapeutic use. This study was focused to investigate the in vitro genotoxic effects of mangiferin in the Ames test, SOS Chromotest and Comet assay. The genotoxic effects in bone marrow erythrocytes from NMRI mice orally treated with mangiferin (2000 mg/kg) were also evaluated. Additionally, its potential antimutagenic activity against several mutagens in the Ames test and its effects on CYP1A1 activity were assessed. Mangiferin (50–5000 μg/plate) did not increased the frequency of reverse mutations …

MaleStereochemistryDNA damageBinucleated cellsXanthonesPharmacologyToxicologymedicine.disease_causeAmes testRats Sprague-Dawleychemistry.chemical_compoundMicemedicineAnimalsMangiferinMangiferaPlant StemsChemistryMutagenicity TestsPlant ExtractsGeneral MedicineDNARatsComet assaySOS chromotestComet AssayMicronucleusGenotoxicityFood Science
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